Ebook A Genetic Switch, Third Edition: Phage Lambda Revisited, by Mark Ptashne
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A Genetic Switch, Third Edition: Phage Lambda Revisited, by Mark Ptashne
Ebook A Genetic Switch, Third Edition: Phage Lambda Revisited, by Mark Ptashne
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The first edition of Mark Ptashne's 1986 book describing the principles of gene regulation in phage lambda became a classic in both content and form, setting a standard of clarity and precise prose that has rarely been bettered. This edition is a reprint of the original text, together with a new chapter updating the story to 2004. Among the striking new developments are recent findings on long-range interactions between proteins bound to widely separated sites on the phage genome, and a detailed description of how gene activation works.
- Sales Rank: #193576 in Books
- Brand: Brand: Cold Spring Harbor Laboratory Press
- Published on: 2004-04-08
- Original language: English
- Number of items: 1
- Dimensions: 6.60" h x .40" w x 9.00" l, .70 pounds
- Binding: Paperback
- 164 pages
- Used Book in Good Condition
Most helpful customer reviews
1 of 1 people found the following review helpful.
A model for well-written scientific books
By R. O. Bjarnason
This classic text explains the structure and function of an epigenetic switch employed by the incredibly simple genome of a common virus.
It reads like a code review of an ingenious piece of software. It starts with a high level overview and iterates to reveal more detail. Every detail is then traced back to an actual reproducible experiment. So at the end we don't only know how the phage works, but also how we know it.
The Kindle version does have a few typesetting problems that interfere mildly with comprehension of the material.
1 of 1 people found the following review helpful.
a clear and deep treatment -- highly recommended
By Stanley Lippman
dr. ptashne is one of the most lucid science writers on the molecular underpinnings of genetic control of transcription -- i have never read a more clearly presented work without any attempt to puff it up, or become obscure. the primary focus of the text is the genetic switches that determine whether in phage becomes dormant within the bacterial cell it has invaded or instead becomes, well, viral. and dr. ptashne walks us through the issues, the controlling genes, and the pathways that trigger its awakening within a dormant host. if you care about this level of molecular control, and it is not your profession, but just a passion, you could not ask for a better guide ....
1 of 1 people found the following review helpful.
A classic book on bacterial gene regulation
By Michael McShan
"A Genetic Switch" by Mark Ptashne is a modern classic of science writing. This book details the mechanism and presents the supporting data for the paradigm of bacterial gene regulation, the bacteriophage lambda repressor. What sets this book apart is not just the subject matter, but the clarity of Ptashne's writing and the superb illustrations that accompany his text. The combination of the two make the book useful for graduate students but also accessible for the general reader with an interest in science. Whenever new people join my laboratory, I have them read this book. Highly recommended.
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